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Management of an Unresponsive Patient with Severe Acidosis

机译:治疗严重酸中毒无反应的患者

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Case ReportCongestive heart failure (CHF) is a chronic medical condition whoseincidence is rising. The prevalence of CHF is approximately 1% to3% in Western countries.1 Despite innovations in medical therapy,CHF is associated with high morbidity and mortality rates.2CHF patients commonly experience muscle weakness andfatigue as two major symptoms. An altered intracellularhandling of ionized calcium has been suggested to play a vitalrole in impaired myocardial contraction.3 In isolated myocytesfrom patients with end stage heart failure, systolic ionizedcalcium levels were markedly decreased, while diastolic levelswere elevated as compared to healthy controls.4 In addition,digitalis and beta-blocker medical therapy is frequently usedin CHF patients and is known to increase myocardial ionizedcalcium levels.5The patient’s past medical history was notable for fibromyalgiaand migraine headaches, and her past surgical history includeda tonsillectomy. Her past psychiatric history was significant fordepression and a prior suicide attempt, involving wrist slitting.The patient had no known drug allergies and her medicationsincluded valium, topamax, oxycontin, percocet and lunesta asneeded. She did not take any over the counter medications orherbal supplements. The patient consumed alcohol occasionallyand smoked cigarettes, but did not use any illicit drugs. Herfamily history was unremarkable.
机译:病例报告充血性心力衰竭(CHF)是一种慢性疾病,其发病率正在上升。在西方国家,CHF的患病率约为1%至3%。1尽管进行了药物治疗方面的创新,但CHF仍具有较高的发病率和死亡率。2CHF患者通常会出现肌肉无力和疲劳这两个主要症状。已建议改变细胞内离子钙的处理方式对受损的心肌收缩起重要作用。3与健康对照组相比,末期心力衰竭患者离体心肌细胞的收缩离子钙水平显着降低,而舒张水平升高。4 CHF患者经常使用洋地黄和β受体阻滞剂药物治疗,并且已知会增加心肌离子钙水平。5该患者的既往病史因纤维肌痛和偏头痛而著名,她的手术史包括扁桃体切除术。她过去的精神病史是严重的抑郁症,此前曾尝试自杀,包括手腕裂开。该患者没有已知的药物过敏,需要治疗的药物包括缬氨酸,托帕麦斯,奥昔康,percocet和月经。她没有服用任何非处方药草药补充剂。病人偶尔饮酒和抽烟,但不使用任何非法药物。家族历史不算多。

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